VITAMIN D3 SUPPRESSES CLASS II INVARIANT CHAIN PEPTIDE EXPRESSION ON ACTIVATED B-LYMPHOCYTES: A PLAUSIBLE MECHANISM FOR DOWNREGULATION OF ACUTE INFLAMMATORY CONDITIONS

Class II invariant chain peptide (CLIP) expression has been demonstrated to play a pivotal role in the regulation of B cell function after nonspecific polyclonal expansion.Several studies have shown vitamin D3 helps regulate the immune response.We hypothesized that activated vitamin D3 suppresses CLIP expression on activated B-cells after nonspecif

The Human Protein Atlas is a website of protein expression in human tissues.It is an excellent resource of tissue and cell type protein localization, but only allows the query of a single protein at a time.We introduce HPAStainR as a new HERBATINT 7R Shiny app and Bioconductor/R package used to query the scored staining patterns in the Human Protei

Abstract Clearance Protein arginine methyltransferase 5 (PRMT5) catalyzes mono-methylation and symmetric di-methylation on arginine residues and has emerged as a potential antitumor target with inhibitors being tested in clinical trials.However, it remains unknown how the efficacy of PRMT5 inhibitors is regulated.Here we report that autophagy block

The circular bioeconomy requires the search for innovative solutions for the management of waste in the food supply chain, especially when it is possible to extract bioproducts with high market demand through innovative green processes.The cactus pear supply chain is not exempt from this process, as its production waste contains Clearance pectin (a